Diastereoselective Alkylation of Activated Nitrogen Heterocycles with Alkenyl Boronate Complexes
نویسندگان
چکیده
Alkenyl boronate complexes react with acylated quinolines and isoquinolines via 1,2-metalate rearrangement to give alkylated, dearomatized heterocycles in good yields, diastereoselectivities, regioselectivities. This multi-component coupling is highly modular can be used access a wide scope of heterocyclic scaffolds. Chiral boronic esters made through this methodology possess high synthetic potential transformed into various functional groups one step without racemization.
منابع مشابه
Homologation and alkylation of boronic esters and boranes by 1,2-metallate rearrangement of boronate complexes.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2023
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/ange.202216961